Statistical and Computational Methods for Marine Ecosystems

Christian Müller
Helmholtz Zentrum & LMU
München, Flatiron Institute

A paramount challenge in modern oceanography is the analysis and integration of its large and diverse datasets, ranging from global remote sensing data to sequencing-derived microbial abundances from cruises or marine stations. Statistical modeling, paired with modern machine-learning and optimization methods, can play a pivotal role in combining these large-scale datasets to gain a holistic, coherent picture of the underlying marine ecosystems and their interactions with the environment. The CBIOMES collaboration provides an ideal environment for fostering such data-and model-driven research in marine ecosystems thanks to the high degree of multi-disciplinary expertise.

Over the first funding period of CBIOMES, the Müller group established strong collaborations with several CBIOMES groups and contributed statistical modeling, optimization, and software expertise to several (ongoing) projects, in particular those involving microbial sequencing data. In Phase II we look forward to building on these collaborative projects with a view to exploring unsupervised learning as a tool to identify ocean provinces from remote sensing data, building statistical models to explore ocean microbiome-environment associations, using tree-aggregated learning for causal inference in ocean data, and joint modeling of flow cytometry and amplicon data.

CBIOMES Collaborators working with Müller

News from the Müller Group

December 2023 CBIOMES e-meeting Viet Tran (Müller Group)

"Learning Ocean Provinces” Please note access to this page is restricted to CBIOMES associates. (more…)

CBIOMES Welcomes Diana David-Rus

A warm welcome to Müller Group Senior Research Scientist Diana David-Rus who recently joined CBIOMES. (more…)

NEW CBIOMES PUBLICATION

Crispin M. Mutshinda, Aditya Mishra, Zoe V. Finkel and Andrew J. Irwin (2023), Density regulation amplifies environmentally induced population fluctuations, PeerJ, doi: 10.7717/peerj.14701 Get the PDF [Requires login]  

CBIOMES Welcomes Viet Tran

A warm welcome to graduate student Viet Tran who recently joined the Müller Group. (more…)

NEW CBIOMES PUBLICATION

Crispin M. Mutshinda, Aditya Mishra, Zoe V. Finkel, Claire E. Widdicombe & Andrew J. Irwin (2022), Bayesian two-part modeling of phytoplankton biomass and occurrence, Hydrobiologia, doi: 10.1007/s10750-021-04789-2 Get the PDF [Requires...

A Systems Level Approach to Biogeography

Microbial simulations bridge the gap between the molecular and ecosystem scales. A new CBIOMES paper presents, for the first time, an interpretation of observed, strain-level, basin-scale biogeography using genome-scale modeling...

NEW CBIOMES PUBLICATION

Jacob Bien, Yan, X., Simpson, L., Christian L. Müller (2021), Tree-aggregated predictive modeling of microbiome data, Scientific Reports, doi: 10.1038/s41598-021-93645-3 Get the PDF [Requires login]  

Recordings and microtalks from the Müller Group. Please note access to this page is restricted to CBIOMES associates. (more…)

2020 Joint Simons Marine Collaborations Meeting

Please note access to this page is restricted to CBIOMES associates only. Besides CBIOMES, the Simons Foundation supports three other marine collaborations: BIOS-SCOPE, PriME, and SCOPE. A joint meeting, October...

The Müller Group goes to Annual Meeting

The Flatiron-CBIOMES group seeks to develop advanced statistical methods for ocean microbiome data analysis. In this video, Christian presents an overview of his team's work and collaborations. Please note access...

CBIOMES at CMStatistics2019

In December, several from CBIOMES traveled to London, England, to present their work at CMStatistics2019, a conference organized by the European Research Consortium for Informatics (ERCIM) Working Group on Computational...